Production and characterization of lipid microparticles produced by. In vivo evaluation of solid lipid microparticles and. Abstract objectives the aims of this study were to evaluate the suitability of the spray congealing technique to produce solid lipid microparticles. Spray congealed solid lipid microparticles for the sustained.
The low encapsulation efficiency of conventional solid lipid microparticles slms especially for hydrophilic drugs has remained a challenge to drug formulation. Lipid based formulations have been used for delivery of lipophilic drugs, with several successfully marketed products, due to good biocompatibility and low toxicity of lipids. Luigi battaglia, marina gallarate, pier paolo panciani, elena ugazio, simona sapino, elena peira and daniela chirio july 25th 2014. Sustained release biodegradable solid lipid microparticles. They can be visualized by means of ld measurements. The full text of this article is available as a pdf 478k.
The objectives of this research were to study the encapsulation of beta. An effective lipid based technology for controlled drug delivery article pdf available january 2012 with 1,357 reads how we measure reads. This means that pcs is a good tool to characterize nanoparticles, but it is not able to detect larger microparticles. To formulate and determine the release profile of zidovudine aztloaded solidified lipid microparticles slms. The prepared lipid microparticles are then dispersed in a cold emulsifier solution at or below room temperature. Evaluation of solid lipid microparticles produced by spray. The temperature should be regulated effectively to ensure the solid state of the. Then this presuspension is homogenized at or below room. Research in solid lipid excipients has increased greatly in the past two decades and are now considered alternative materials to biodegradable polymers for sustained drug delivery due to the physical.
The mpls were produced by spray cooling from solid and liquid lipid mixtures stearic and oleic fatty acids and partly hydrogenated vegetable fat containing. Formulation and release characteristics of zidovudine bioline. Preparation and in vivo toxicity study of solid lipid microparticles as. Development and characterization of solidlipid microparticles of. Pdf techniques for the preparation of solid lipid nano.
Slm are characterized by their better biocompatibility as compared to competing polymeric microparticles 9. For preparing nebivolol loaded solid lipid microparticles. Techniques for the preparation of solid lipid nano and microparticles, application of nanotechnology in drug delivery, ali demir sezer, intechopen, doi. Techniques for the preparation of solid lipid nano and. Slms by the solvent evaporation microencapsulation pro cess from carnauba wax. Formulation and evaluation of novel solid lipid microparticles as a. Water uptake of spray congealed lipid microparticles after.